The role of oxidative energy metabolism in determining exercise tolerance in physiological and pathological conditions. Identification of pathophysiological mechanisms and functional evaluation tools in a translational perspective

  • Udine
  • Tempo determinato
  • Full time
  • 17 giorni fa
Offer DescriptionThe activity of the research group deals, in general terms, with environmental, exercise and clinical physiology, with a specific interest in oxidative energy metabolism and exercise tolerance, both in physiological and in pathological conditions. Research is conducted within a translational approach, aimed at transferring methods and approaches developed in research laboratories to men and to the patients' bedside. Specific topics of interest comprehend the physiological adjustments to microgravity/physical inactivity/disuse, as well as the physiology of ageing, with specific reference to sarcopenia. Examples of pathological conditions which are studied comprehend patients with the long-Covid syndrome, patients with chronic obstructive pulmonary diseases or obesity. In these patients, besides the identification of pathophysiological mechanisms, the ultimate aim is to identify preventive, therapeutical or rehabilitative approaches, with specific reference to an individualized prescription of physical activity (“exercise is medicine”). Specific aims are the identification and the utilization of non-invasive methods evaluating exercise tolerance, microvascular/endothelial function, skeletal muscle oxidative metabolism, as well as methods to evaluate mitochondrial respiration and mitochondrial function/dysfunction.
The researcher will work in these research fields, both in terms of basic and applied research, He/she will specifically pursue: a) integrative aspects between the organs and systems involved; b) molecular and cellular aspects, possibly also on animal models; c) identification of biomarkers of impairment, along the pathway for O2 from ambient air to the mitochondria of skeletal muscles, to be ideally utilized on patients for their functional evaluation and for the implementation of preventive, therapeutical or rehabilitative approaches.
Within the Exercise Physiology Laboratory of the Department several projects are ongoing, mainly financed by the Italian Ministry of Research: PRIN 2020: “Inactivity-induced neuromuscular impairment through different ages: from children, to young and middle age adults [InactivAge]”. PRIN 2022: “Long-COVID syndrome: pathophysiology of the impaired exercise tolerance”. PRIN 2022 PNRR: “Central (cardiorespiratory) and peripheral (muscular) determinants of functional deterioration in COPD: new biomarkers for evaluating disease severity and acute exacerbations?”.RequirementsAdditional InformationWork Location(s)Number of offers available 1 Company/Institute Università degli Studi di Udine Country Italy State/Province UD City udine Postal Code 33050 Street via palladio 8 GeofieldWhere to apply WebsiteContact State/ProvinceUD Cityudine WebsiteStreetvia palladio 8 Postal Code33050 E-Mailconcorsidoc@uniud.itSTATUS: EXPIRED

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